In 1886, the Scanlons, a prominent real estate family in Galveston, purchased land and built two buildings known as the Levy Building and the Star Drug Store.
In the 1920's George Clampitt and Grady Dickinson purchased and operated the store until 1982. These two men maintained the integrity of the drug store as well as altered history when the Star became the first desegregated lunch counter in Galveston.
Ownership changed hands several times before a severe fire on Friday, March 13, 1998, closed the store indefinitely. In November 2001, the Tilts family purchased and began restorations to the building.
On September 12, 2008, Galveston experienced a devastating disaster, Hurricane Ike. The Star Drug Store sustained over six and half feet of water inside its premises damaging most of the downstairs furniture, equipment and retail items. With the dedication and help of family, friends and co-workers, the Star reopened three months later on December 17, to once again serve its beloved patrons.